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リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T7603	Pinaverium bromide		Calcium Channel
	Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.		Calcium Channel
T12015	Methyl homoveratrate		Others
	Methyl homoveratrate, a McN5691 (RWJ-26240) metabolite detected in vivo in plasma, urine, and fecal extracts, functions as a voltage-sensitive calcium channel blocker.		Others
T15423	GSK-7975A		Calcium Channel
	GSK-7975A is a potent and orally available inhibitor of CRAC channel.		Calcium Channel
T8863	VK-II-36		Others
	VK-II-36, a carvedilol analog, suppresses sarcoplasmic reticulum (SR) Ca(2+) release but does not block the β-receptor.		Others
T10659	Ca2+ channel agonist 1		Calcium Channel , CDK
	Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.		Calcium Channel , CDK
T10690	Cav 2.2 blocker 1		Calcium Channel
	Cav 2.2 blocker 1 is an N-type calcium channel (Cav 2.2; IC50: 1 nM) blocker for the treatment of pain.		Calcium Channel
T11517	GV-58		Calcium Channel
	GV-58 is a selective N- and P/Q-type Ca2+ channels agonist (EC50: 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel). The inhibitory of GV-58 is 20-fold fewer for CDK kinases activity.		Calcium Channel
T7373	CDN1163		Calcium Channel
	CDN1163 is a small molecule activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).		Calcium Channel
T3543	NS-638	NS 638	Calcium Channel
	NS-638 is a Ca2+-channel blocker. It can block K+-stimulated intracellular Ca2+-elevation (IC50: 3.4 μM).		Calcium Channel
T22788	FPL64176	FPL 64176	Calcium Channel
	FPL64176 is a L-type calcium channels activator.		Calcium Channel
T3703	ABT-639	ABT 639	Calcium Channel
	ABT-639 is a potent and selective T-type calcium channel blocker.		Calcium Channel
T0388	Cilnidipine	FRC-8653	Calcium Channel
	Cilnidipine (FRC-8653)(FRC8653) is a dual L- and N-type calcium channel blocker and displays antihypertensive, sympatholytic and neuroprotective activity.		Calcium Channel
T7216	Mirogabalin	DS5565	Calcium Channel
	Mirogabalin (DS5565) is a calcium channel blocker with analgesic effects.		Calcium Channel
T0702	Gabapentin	Neurontin,Gabapentine,Aclonium	Calcium Channel , GABA Receptor
	Gabapentin (Neurontin) is an Anti-epileptic Agent. The physiologic effect of gabapentin is by means of Decreased Central Nervous System Disorganized Electrical Activity.		Calcium Channel , GABA Receptor
T2519	Lercanidipine	Masnidipine	Calcium Channel
	Lercanidipine (Masnidipine) is a calcium channel blocker of the dihydropyridine class.		Calcium Channel
T29201	Z944	Z 944,Z-944	Calcium Channel
	Z944 is a T-type calcium channel blocker. Z944 delays the progression of seizures in the amygdala kindling model. Z944 disrupts prepulse inhibition in both epileptic and non-epileptic rats.		Calcium Channel
T5632	Suvecaltamide	MK-8998	Calcium Channel
	Suvecaltamide (MK-8998) as potent inhibitors of T-type calcium channels.		Calcium Channel
T11353	Gallopamil	Methoxyverapamil	Calcium Channel
			Calcium Channel
T6577	Manidipine	Iperten,Franidipine,Artedil	Calcium Channel
	Manidipine (Iperten), a calcium channel blocker, which is dihydropyridine type. It is utilized		Calcium Channel
T0327	Fendiline hydrochloride	Fendiline HCl	Calcium Channel
	Fendiline hydrochloride (Fendiline HCl) is a non-selective blocker of calcium channel.		Calcium Channel
T14844	BX430		P2X Receptor , Calcium Channel
	BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity.		P2X Receptor , Calcium Channel
T6848	GSK1016790A	GSK101	Calcium Channel , TRP/TRPV Channel
	GSK1016790A (GSK101) (GSK101) is a novel, potent activator of TRPV4 (transient receptor potential vanilloid 4) with EC50 of 34 nM in choroid plexus epithelial cells.		Calcium Channel , TRP/TRPV Channel
T5376	Aranidipine	MPC1304	Calcium Channel
	Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects.		Calcium Channel
T11353L	Gallopamil hydrochloride	Methoxyverapamil hydrochloride	Calcium Channel
			Calcium Channel
T23280	Ruthenium Red	Ammoniated ruthenium oxychloride	Calcium Channel
	Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ...		Calcium Channel
T0903	Cinnarizine	Stugeron,Cinarizine,Dimitronal,Stutgin	Calcium Channel , Histamine Receptor
	Cinnarizine (Stugeron) is a piperazine derivative having histamine H1-receptor and calcium-channel blocking activity with vasodilating and antiemetic properties but it induces PARKINSONIAN DISORDERS.		Calcium Channel , Histamine Receptor
T16873	SERCA2a activator 1		Calcium Channel
	SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.		Calcium Channel
T0163	Nisoldipine	BAY-k 5552	Calcium Channel , Reactive Oxygen Species
	Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.		Calcium Channel , Reactive Oxygen Species
T15257	Etripamil	MSP-2017,(-)-MSP-2017	Calcium Channel
	Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells...		Calcium Channel
T16571	Pranidipine	OPC-13340	Calcium Channel
	Pranidipine (OPC-13340) is a novel, long-acting 1,4-dihydropyridine calcium channel blocker. It prolongs acetylcholine-induced relaxation in presence of endothelium as well as nitroglycerin-induced relaxation in absence ...		Calcium Channel
T5023	Propiverine hydrochloride		Others , Calcium Channel , AChR
	Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).		Others , Calcium Channel , AChR
T0916	Butamben	Butyl 4-aminobenzoate	Potassium Channel , Calcium Channel , Sodium Channel
	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.		Potassium Channel , Calcium Channel , Sodium Channel
T8674	SR33805		Calcium Channel
	SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)		Calcium Channel
T4669	Fantofarone	SR 33557	Calcium Channel , Parasite
	Fantofarone (SR 33557) is a highly potent antagonist of Calcium Channel.		Calcium Channel , Parasite
T1385	Amlodipine	UK-48340	Calcium Channel
	Amlodipine (UK-48340) is a synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties.		Calcium Channel
T0999	Clevidipine	Clevidipine butyrate,Cleviprex	Calcium Channel , AChR
	Clevidipine (Clevidipine butyrate) is a dihydropyridine L-type calcium channel blocker that is selective for vascular smooth muscle and is indicated for blood pressure reduction when oral therapy is not an option.		Calcium Channel , AChR
T1545	Levamlodipine	(S)-Amlodipine,S-amlodipine	Calcium Channel
	Levamlodipine (S-amlodipine) belongs to the dihydropyridine group of calcium channel blockers. Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of amlodipine, an antihypertensive and an...		Calcium Channel
T2323	Efonidipine	(±)-Efonidipine,NZ-105	Calcium Channel
	Efonidipine (NZ-105)(NZ-105) is a dihydropyridine calcium channel blocker, blocking both T-type and L-type calcium channels.		Calcium Channel
T6633	Ranolazine	CVT 303,Ranexa,RS 43285-003	Calcium Channel , Sodium Channel
	Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the...		Calcium Channel , Sodium Channel
T0231	Amlodipine Besylate	Amlodipine benzenesulfonate	Calcium Channel
	Amlodipine Besylate(Amlodipine benzenesulfonate) is a long-lasting calcium channel blocker.		Calcium Channel
T0030	Bupivacaine hydrochloride	Vivacaine,Bupivacaine HCl	Sodium Channel
	Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the vol...		Sodium Channel
T8944	TTA-A2		Calcium Channel
	TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ...		Calcium Channel
T6507	Gabapentin hydrochloride	Neurontin HCl,Gabapentin HCl	Calcium Channel , GABA Receptor
	Gabapentin hydrochloride (Neurontin HCl) is a GABA analogue, used to treat seizures and neuropathic pain.		Calcium Channel , GABA Receptor
T12238	NNC 55-0396	NNC 55-0396 dihydrochloride	Calcium Channel
	NNC 55-0396 is a highly selective blocker of T-type calcium channel with IC50 of 6.8 μM. NNC 55-0396 can be used in studies about preventing human ovarian cancer cell proliferation.		Calcium Channel
T5391	Bepridil hydrochloride	CERM 1978	Calcium Channel
	Bepridil hydrochloride (CERM 1978) is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.		Calcium Channel
T0145	Felodipine	CGH-869	Calcium Channel , Autophagy
	Felodipine (CGH-869) is a longlasting 1, 4-dihydropyridine calcium channel repressor.		Calcium Channel , Autophagy
T0343	Nimodipine	BAY-e 9736	Glucocorticoid Receptor , AhR , Calcium Channel , Autophagy
	Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.		Glucocorticoid Receptor , AhR , Calcium Channel , Autophagy
T4693	2-Aminoethyl diphenylborinate	2-Aminoethoxydiphenyl borate,2-APB	Calcium Channel , TRP/TRPV Channel
	2-Aminoethyl diphenylborinate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations).		Calcium Channel , TRP/TRPV Channel
T0858	Flufenamic acid	Arlef,Nichisedan,Achless	Potassium Channel , Calcium Channel , Chloride channel , COX , AMPK , Parasite
	Flufenamic acid (Arlef) is an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties. It is used in musculoskeletal and joint disorders and administered by mouth and topically.
T15053	Darodipine	PY-108068,PY 108-068	Calcium Channel
	Darodipine (PY-108068) is a dihydropyridine type Ca+2 antagonist.		Calcium Channel

Compounds

Pinaverium bromide

T7603

Synonym:

Target: Calcium Channel

Target: Calcium Channel

Ca2+ channel agonist 1

T10659

Synonym:

Target: Calcium Channel, CDK

Cav 2.2 blocker 1

T10690

Synonym:

Target: Calcium Channel

GV-58

T11517

Synonym:

Target: Calcium Channel

CDN1163

T7373

Synonym:

Target: Calcium Channel

NS-638

T3543

Synonym: NS 638

Target: Calcium Channel

FPL64176

T22788

Synonym: FPL 64176

Target: Calcium Channel

ABT-639

T3703

Synonym: ABT 639

Target: Calcium Channel

Cilnidipine

T0388

Synonym: FRC-8653

Target: Calcium Channel

Mirogabalin

T7216

Synonym: DS5565

Target: Calcium Channel

Gabapentin

T0702

Synonym: Neurontin,Gabapentine,Aclonium

Target: Calcium Channel, GABA Receptor

Lercanidipine

T2519

Synonym: Masnidipine

Target: Calcium Channel

Z944

T29201

Synonym: Z 944,Z-944

Target: Calcium Channel

Suvecaltamide

T5632

Synonym: MK-8998

Target: Calcium Channel

Gallopamil

T11353

Synonym: Methoxyverapamil

Target: Calcium Channel

Manidipine

T6577

Synonym: Iperten,Franidipine,Artedil

Target: Calcium Channel

Fendiline hydrochloride

T0327

Synonym: Fendiline HCl

Target: Calcium Channel

BX430

T14844

Synonym:

Target: P2X Receptor, Calcium Channel

GSK1016790A

T6848

Synonym: GSK101

Target: Calcium Channel, TRP/TRPV Channel

Aranidipine

T5376

Synonym: MPC1304

Target: Calcium Channel

Gallopamil hydrochloride

T11353L

Synonym: Methoxyverapamil hydrochloride

Target: Calcium Channel

Ruthenium Red

T23280

Synonym: Ammoniated ruthenium oxychloride

Target: Calcium Channel

Cinnarizine

T0903

Synonym: Stugeron,Cinarizine,Dimitronal,Stutgin

Target: Calcium Channel, Histamine Receptor

SERCA2a activator 1

T16873

Synonym:

Target: Calcium Channel

Nisoldipine

T0163

Synonym: BAY-k 5552

Target: Calcium Channel, Reactive Oxygen Species

Etripamil

T15257

Synonym: MSP-2017,(-)-MSP-2017

Target: Calcium Channel

Pranidipine

T16571

Synonym: OPC-13340

Target: Calcium Channel

Propiverine hydrochloride

T5023

Synonym:

Target: Others, Calcium Channel, AChR

Butamben

T0916

Synonym: Butyl 4-aminobenzoate

Target: Potassium Channel, Calcium Channel, Sodium Channel

SR33805

T8674

Synonym:

Target: Calcium Channel

Fantofarone

T4669

Synonym: SR 33557

Target: Calcium Channel, Parasite

Amlodipine

T1385

Synonym: UK-48340

Target: Calcium Channel

Clevidipine

T0999

Synonym: Clevidipine butyrate,Cleviprex

Target: Calcium Channel, AChR

Levamlodipine

T1545

Synonym: (S)-Amlodipine,S-amlodipine

Target: Calcium Channel

Efonidipine

T2323

Synonym: (±)-Efonidipine,NZ-105

Target: Calcium Channel

Ranolazine

T6633

Synonym: CVT 303,Ranexa,RS 43285-003

Target: Calcium Channel, Sodium Channel

Amlodipine Besylate

T0231

Synonym: Amlodipine benzenesulfonate

Target: Calcium Channel

Bupivacaine hydrochloride

T0030

Synonym: Vivacaine,Bupivacaine HCl

Target: Sodium Channel

TTA-A2

T8944

Synonym:

Target: Calcium Channel

Gabapentin hydrochloride

T6507

Synonym: Neurontin HCl,Gabapentin HCl

Target: Calcium Channel, GABA Receptor

NNC 55-0396

T12238

Synonym: NNC 55-0396 dihydrochloride

Target: Calcium Channel

Bepridil hydrochloride

T5391

Synonym: CERM 1978

Target: Calcium Channel

Felodipine

T0145

Synonym: CGH-869

Target: Calcium Channel, Autophagy

Nimodipine

T0343

Synonym: BAY-e 9736

Target: Glucocorticoid Receptor, AhR, Calcium Channel, Autophagy

2-Aminoethyl diphenylborinate

T4693

Synonym: 2-Aminoethoxydiphenyl borate,2-APB

Target: Calcium Channel, TRP/TRPV Channel

Flufenamic acid

T0858

Synonym: Arlef,Nichisedan,Achless

Target: Potassium Channel, Calcium Channel, Chloride channel, COX, AMPK, Parasite

Darodipine

T15053

Synonym: PY-108068,PY 108-068

Target: Calcium Channel

カタログ番号	製品名	別名	ターゲット
TN2322	Yangambin		Calcium Channel , PAFR
	Yangambin is a selective antagonist of the cardiovascular effects of platelet activating factor (PAF); it has hypotensive effect, which is probably due to a peripheral vasodilatation that involves, at least, the inhibiti...		Calcium Channel , PAFR
T6S1418	Praeruptorin C		Antioxidant , Calcium Channel
	1. Praeruptorin C has been widely used as an antioxidant and a calcium antagonist to treat diseases. 2. Praeruptorin C partially protects cortical neurons by inhibiting the expression of GluN2B-containing NMDA receptors ...		Antioxidant , Calcium Channel
T8787	Drotaverine hydrochloride		PDE
	Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela...		PDE
T8206	Cycleanine		Others
	Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities.		Others
T0728	Ethosuximide	Zarontin	Calcium Channel
	Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.		Calcium Channel
T3904	Gomisin J		Calcium Channel , AMPK
	Gomisin J is a natural product and have vasodilatory activity. Gomisin J suppresses lipid accumulation by regulating the expression of lipogenic and lipolytic enzymes and inflammatory molecules through activation of AMPK...		Calcium Channel , AMPK
T5723	Menthol	DL-Menthol	Others , Calcium Channel
	Menthol (DL-Menthol) is an organic compound made synthetically or obtained from peppermint or mint oils with flavoring and local anesthetic properties.		Others , Calcium Channel
T15027	Cyclopiazonic acid		Calcium Channel
	Cyclopiazonic acid (CPA) is a neurotoxic secondary metabolite (SM) made by A. flavus. Cyclopiazonic acid (CPA) is an endoplasmic reticulum calcium ATPase (Ca2+ATPase; SERCA)nanomolar inhibitor and a potent inducer of ce...		Calcium Channel
T4S1422	Praeruptorin E		Others , Calcium Channel
	1. Praeruptorin C and E can relax swine coronary artery and decrease contractility in guinea-pig left atria, these effects are similar in many respects to those displayed by drugs that have calcium entry blocking activit...		Others , Calcium Channel
T10024	1-Octanol	Octanol	Calcium Channel , Endogenous Metabolite
	1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized ...		Calcium Channel , Endogenous Metabolite
TQ0302	Thapsigargin		Apoptosis , SARS-CoV , Calcium Channel
	Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ...		Apoptosis , SARS-CoV , Calcium Channel
T3013	Catharanthine tartrate	Catharanthine hemitartrate	Others , Calcium Channel
	Catharanthine tartrate (Catharanthine hemitartrate) is an alkaloid from periwinkle that inhibits voltage-gated L-type calcium channels and has antitumor and hypotensive activities.		Others , Calcium Channel
TN1008	Psoralenoside		CaMK , Calcium Channel , Histamine Receptor
	Psoralenoside is a natural product isolated from the fruits of Psoralea corylifolia, shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.		CaMK , Calcium Channel , Histamine Receptor
T2782	Catharanthine	(+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine	Calcium Channel , AChR
	Catharanthine ((+)-3,4-Didehydrocoronaridine) suppresses nicotinic receptor-mediated diaphragm contractions (IC50=59.6 μM).		Calcium Channel , AChR
T4590	(+)-Kavain	Kavain,L-KAWAIN,(R)-KAWAIN	Calcium Channel , GABA Receptor , Sodium Channel , Monoamine Transporter
	(+)-Kavain ((R)-KAWAIN) is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.
T6S1500	Ginsenoside Rf	Ginsenoside-Rf,Panaxoside Rf	Calcium Channel , Endogenous Metabolite
	Ginsenoside Rf (Panaxoside Rf) is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.		Calcium Channel , Endogenous Metabolite
T4727	Taurolithocholic acid sodium salt	Sodium taurolithocholate	Others , Calcium Channel
	Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.		Others , Calcium Channel
TN7108	Urolithin C		Apoptosis , Calcium Channel , Reactive Oxygen Species , IGF-1R , Endogenous Metabolite
	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T4S1419	(±)-Praeruptorin A	Praeruptorin A,(-)-Praeruptorin A	p38 MAPK , Calcium Channel , Akt
	1. (±)-Praeruptorin A could exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation 2. Praeruptorin A has the potential to inhibit migration/fusion ...		p38 MAPK , Calcium Channel , Akt
T5701	OPHIOPOGONIN D		RAAS , Calcium Channel , NF-κB , PPAR
	Ophiopogonin D is a natural product,and is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation.		RAAS , Calcium Channel , NF-κB , PPAR
T3S1916	Heteroclitin D		Calcium Channel
	1. Heteroclitin D can inhibit L-type calcium channels. 2. Heteroclitin D might be a valuable antitumor promoter or chemopreventor.		Calcium Channel
T7056	Dronedarone	SR 33589	P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T1221	Acetylcholine chloride	ACh chloride,Pilofrin	Calcium Channel , Endogenous Metabolite , AChR
	Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...		Calcium Channel , Endogenous Metabolite , AChR
T8288	14-Deoxyandrographolide		Apoptosis , Others
	14-Deoxyandrographolide is a bioactive compound of Andrographis paniculata with hepatoprotective efficacy. It desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release.		Apoptosis , Others
T6856	Halofuginone	Tempostatin,empostatin,RU-19110	Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal.
T5S2059	Glaucine		Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
T11665	Ionomycin calcium	SQ23377 calcium	Apoptosis , Calcium Channel , Antibacterial , Antibiotic , PKC

T3524	Halofuginone hydrobromide	Tempostatin,RU-19110 (hydrobromide),Stenorol	Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad
	Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce...
T3915	Ginsenoside Ro	Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V	Calcium Channel , Reductase , Prostaglandin Receptor
	Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM.		Calcium Channel , Reductase , Prostaglandin Receptor
T2878	Ginsenoside Rd	Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII	P450 , Calcium Channel , NF-κB , COX , Endogenous Metabolite
	Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.
T2996	Tetrandrine	NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A	Potassium Channel , Calcium Channel
	Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the c...		Potassium Channel , Calcium Channel
T3377	L-Phenylalanine	(S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine	Calcium Channel , Endogenous Metabolite , iGluR
	L-Phenylalanine (3-Phenyl-L-alanine) is an essential amino acid and the precursor of the amino acid tyrosine, acts as an antagonist at α2δ calcium channels.		Calcium Channel , Endogenous Metabolite , iGluR
T0928	L-Ascorbic acid	Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate	Apoptosis , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
	L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-...
T6674	L-Ascorbic acid sodium salt	(+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate	Apoptosis , Others , Calcium Channel , Reactive Oxygen Species , Endogenous Metabolite
	L-Ascorbic acid sodium salt (Vitamin C sodium salt) is a more bioavailable form of vitamin C that is an alternative to taking ascorbic acid as a supplement.
TN5234	Vindorosine		Calcium Channel , Sodium Channel
	Vindorosine has blood vessel relaxation effect, possible underlying mechanisms involving the inhibition of Ca(2+) entry via L-type Ca(2+) channels in vascular smooth muscles.		Calcium Channel , Sodium Channel
T82764	Cd1a	β-TRTX-cd1a,β-Theraphotoxin-cd1a
	Cd1a, a β-toxin from the African spider Ceratogyrus darlingi, modulates calcium ion channels and inhibits human calcium ion channels (Ca v 2.2)(IC 50 2.6 μM) as well as mouse sodium ion channels (Na v 1.7). This compound...
TN2534	1-Hydroxy-2,3,5-trimethoxyxanthone		IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX
	1-Hydroxy-2,3,5-trimethoxyxanthone (HM-1) has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type vo...		IκB/IKK , Calcium Channel , NOS , 5-HT Receptor , COX
T74193	(R)-IDHP
	(R)-IDHP, an isomer of IDHP and a metabolite of salvia, exhibits vasorelaxant properties by inhibiting calcium (Ca 2+) release and inward flow through both voltage-dependent and receptor-operated calcium channels in vasc...

天然物製品

Yangambin

TN2322

Synonym:

Target: Calcium Channel, PAFR

Praeruptorin C

T6S1418

Synonym:

Target: Antioxidant, Calcium Channel

Drotaverine hydrochloride

Target: Calcium Channel

Gomisin J

T3904

Synonym:

Target: Calcium Channel, AMPK

Menthol

T5723

Synonym: DL-Menthol

Target: Others, Calcium Channel

Cyclopiazonic acid

T15027

Synonym:

Target: Calcium Channel

Praeruptorin E

T4S1422

Synonym:

Target: Others, Calcium Channel

1-Octanol

T10024

Synonym: Octanol

Target: Calcium Channel, Endogenous Metabolite

Thapsigargin

TQ0302

Synonym:

Target: Apoptosis, SARS-CoV, Calcium Channel

Catharanthine tartrate

T3013

Synonym: Catharanthine hemitartrate

Target: Others, Calcium Channel

Psoralenoside

TN1008

Synonym:

Target: CaMK, Calcium Channel, Histamine Receptor

Catharanthine

T2782

Synonym: (+)-3, 4-Didehydrocoronaridine,(+)-3,4-Didehydrocoronaridine

Target: Calcium Channel, AChR

(+)-Kavain

T4590

Synonym: Kavain,L-KAWAIN,(R)-KAWAIN

Target: Calcium Channel, GABA Receptor, Sodium Channel, Monoamine Transporter

Ginsenoside Rf

T6S1500

Synonym: Ginsenoside-Rf,Panaxoside Rf

Target: Calcium Channel, Endogenous Metabolite

Taurolithocholic acid sodium salt

T4727

Synonym: Sodium taurolithocholate

Target: Others, Calcium Channel

Urolithin C

TN7108

Synonym:

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, IGF-1R, Endogenous Metabolite

(±)-Praeruptorin A

T4S1419

Synonym: Praeruptorin A,(-)-Praeruptorin A

Target: p38 MAPK, Calcium Channel, Akt

OPHIOPOGONIN D

T5701

Synonym:

Target: RAAS, Calcium Channel, NF-κB, PPAR

Heteroclitin D

T3S1916

Synonym:

Target: Calcium Channel

Dronedarone

T7056

Synonym: SR 33589

Target: P450, Potassium Channel, Calcium Channel, Sodium Channel, Adrenergic Receptor, AChR, Autophagy

Acetylcholine chloride

T1221

Synonym: ACh chloride,Pilofrin

Target: Calcium Channel, Endogenous Metabolite, AChR

14-Deoxyandrographolide

T8288

Synonym:

Target: Apoptosis, Others

Halofuginone

T6856

Synonym: Tempostatin,empostatin,RU-19110

Target: Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Glaucine

T5S2059

Synonym:

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Ionomycin calcium

T11665

Synonym: SQ23377 calcium

Target: Apoptosis, Calcium Channel, Antibacterial, Antibiotic, PKC

Halofuginone hydrobromide

T3524

Synonym: Tempostatin,RU-19110 (hydrobromide),Stenorol

Target: Others, Calcium Channel, DNA/RNA Synthesis, Sodium Channel, Parasite, TGF-beta/Smad

Ginsenoside Ro

T3915

Synonym: Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V

Target: Calcium Channel, Reductase, Prostaglandin Receptor

Ginsenoside Rd

T2878

Synonym: Panaxoside Rd,Sanchinoside Rd,Gypenoside VIII

Target: P450, Calcium Channel, NF-κB, COX, Endogenous Metabolite

Tetrandrine

T2996

Synonym: NSC-77037,d-Tetrandrine,Hanfangchin A,Fanchinine,Sinomenine A

Target: Potassium Channel, Calcium Channel

L-Phenylalanine

T3377

Synonym: (S)-2-Amino-3-phenylpropionic acid,phenylalanine,3-Phenyl-L-alanine

Target: Calcium Channel, Endogenous Metabolite, iGluR

L-Ascorbic acid

T0928

Synonym: Vitamin C,Ascorbic acid,L(+)-Ascorbic acid,L-Ascorbate

Target: Apoptosis, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

L-Ascorbic acid sodium salt

T6674

Synonym: (+)-Sodium L-ascorbate,Vitamin C sodium salt,Sodium ascorbate,L-Ascorbic acid sodium,Sodium L-ascorbate

Target: Apoptosis, Others, Calcium Channel, Reactive Oxygen Species, Endogenous Metabolite

Vindorosine

TN5234

Synonym:

Target: Calcium Channel, Sodium Channel

Cd1a

T82764

Synonym: β-TRTX-cd1a,β-Theraphotoxin-cd1a

Target:

1-Hydroxy-2,3,5-trimethoxyxanthone

TN2534

Synonym:

Target: IκB/IKK, Calcium Channel, NOS, 5-HT Receptor, COX

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPH-01027	CAMK2D Protein, Human, Recombinant (His)	Human	E. coli
	Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in C...
TMPH-01028	KCNMA1 Protein, Human, Recombinant	Human	E. coli
	Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitato...
TMPY-03384	CALM2 Protein, Human, Recombinant (His)	Human	E. coli
	Calmodulin 2, also known as CALM2, is a calmodulin. Calmodulin 2 mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). It is involved in a genetic pathway that regulates the centro...
TMPH-01035	CNR1 Protein-VLP, Human, Recombinant (His)	Human	HEK293
	G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrah...
TMPH-03753	MYLK Protein, Human, Recombinant (His)	Human	E. coli
	Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phos...
TMPH-03256	CNR1 Protein, Rat, Recombinant (His)	Rat	in vitro E. coli expression system
	G-protein coupled receptor for cannabinoids, including endocannabinoids (eCBs), such as N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effe...